The dashing, mysterious Count Dracula (Bela Lugosi), after hypnotizing a British soldier, Renfield (Dwight Frye), into his mindless slave, travels to London and takes up residence in an old castle. Soon Dracula begins to wreak havoc, sucking the blood of young women and turning them into vampires. When he sets his sights on Mina (Helen Chandler), the daughter of a prominent doctor, vampire-hunter Van Helsing (Edward Van Sloan) is enlisted to put a stop to the count's never-ending bloodlust.

While researching a new drug, Dr. Jack Griffin (Claude Rains) stumbles on a potion that can make him invisible. When he reveals his new ability to his old mentor (Henry Travers) and his fiancée (Gloria Stuart), it's clear that a side effect of the potion is insanity. Jack goes on a violent rampage, and the police struggle to hunt him down, unable to see their target, while his mentor and his former partner (William Harrigan) desperately try to devise a plan to capture him.

When his brother dies, Larry Talbot (Lon Chaney) returns to Wales and reconciles with his father (Claude Rains). While there, he visits an antique shop and, hoping to impress Gwen (Evelyn Ankers), the attractive shopkeeper, buys a silver walking cane. That same night he kills a wolf with it, only to later learn that he actually killed a man (Bela Lugosi). A gypsy (Maria Ouspenskaya) explains that it was her son, a werewolf, that he killed, and that Larry is now one himself.

This iconic horror film follows the obsessed scientist Dr. Henry Frankenstein as he attempts to create life by assembling a creature from body parts of the deceased. Aided by his loyal misshapen assistant, Fritz, Frankenstein succeeds in animating his monster, but it escapes into the countryside and begins to wreak havoc. Frankenstein searches for the elusive being and eventually must confront his tormented creation.

In the first of Bud Abbott and Lou Costello's horror vehicles for Universal Pictures, the inimitable comic duo star as railway baggage handlers in northern Florida. When a pair of crates belonging to a house of horrors museum are mishandled by Wilbur (Lou Costello), the museum's director, Mr. MacDougal (Frank Ferguson), demands that they deliver them personally so that they can be inspected for insurance purposes, but Lou's friend Chick (Bud Abbott) has grave suspicions.